"Of Mice and Men": Significance of the Title

The title of every great novel has some significance. Sometimes that significance can clearly be seen and sometimes you really have to analyze the book to figure out the title's significance. The significance of "Of Mice and Men" can be found by analyzing the mice and men of the book.
Mice are soft, smooth, and small fragile animals. They need attention, protection and affection. The "mice" of the book are Lennie, Curley's wife, Candy's old dog, Lennie's puppy, and the dead mouse Lennie had in his pocket at the beginning of the novel. Although Lennie is not small of soft or smooth, he is v…